The international platform of registered systematic review and meta-analysis protocols (INPLASY) at 3 years: an analysis of 4,658 registered protocols on inplasy.com, platform features, and website statistics.

Background: INPLASY® is an international platform for registering systematic reviews and meta-analysis protocols that was launched in March 2020. INPLASY® provides an online database in which the protocols are maintained as permanent public records and can be accessed on its website (www.inplasy.com). Methods: We described the database features and registered information of all records published since the launch of the registry on March 31, 2023. Additionally, we analyzed the website statistics dataset to explore user experience and promote data transparency. Results: Four thousand six hundred fifty-eight records were registered in INPLASY®, and more than 94% of the protocols were published within 24 h. Most of the submissions were from China, followed by Portugal, Taiwan, Malaysia, and Brazil. The INPLASY® website received 386,395 page views from 64,568 visitors during the first three years. The accesses were obtained from 170 countries. Most of the accesses were from China, followed by the US, the UK, and Portugal. The review status "completed and published" was observed in 898 protocols, and these studies were published in 372 different scientific peer-reviewed journals. The features of INPLASY® include the following: (i) INPLASY® identifier, a unique protocol number; (ii) the digital object identifier (DOI) number, the URL of the protocol linked to a specific DOI; (iii) ORCID update, INPLASY® automatically updates authors' ORCID page, including their protocol; and (iv) search tools, the protocols are freely accessible on www.inplasy.com. Conclusions: INPLASY® has several practical and useful features that should be considered when planning the registration of a systematic review protocol. Furthermore, the sharp increase in the number of protocols registered in INPLASY® in the first three years and the database statistics demonstrate that INPLASY® has become an important source of systematic review protocols. Therefore, authors should access INPLASY® before planning a future review study to avoid unintended duplication of efforts and to obtain timely registration.

Comparative efficacy and safety of different corticosteroids to reduce inflammatory complications after mandibular third molar surgery: a systematic review and network meta-analysis.

A variety of corticosteroids are available as an alternative to reduce inflammatory complications after mandibular third molar surgery (3MS). However, it is unclear which are the best preoperative drugs, doses, and routes of administration. A frequentist network meta-analysis was performed to assess the comparative effectiveness of corticosteroids to reduce inflammatory complications after 3MS. We searched Embase, PubMed, and the Cochrane Library without language restrictions. Only randomised clinical trials (RCTs) were included. We obtained the relative effectiveness using network meta-analysis and an estimate of the relative ranking of interventions according to their effects. Our search yielded 2427 results, from which 61 studies involving 3561 subjects fulfilled our inclusion criteria. Five corticosteroids (dexamethasone, betamethasone, methylprednisolone, prednisolone, and triamcinolone) were compared. Dexamethasone 8mg via submucosal injection (-3.58[-6.98; -0.17]) and via pterygomandibular injection (-3.56[-6.30; -0.82]) were significantly more effective than placebo to reduce oedema after 3MS. The ranking analysis showed that dexamethasone 8mg via submucosal injection and via oral tablets were the interventions with the highest probability of being the most effective methods to reduce oedema after 3MS (p values = 0.71 and 0.75, respectively). Compared with placebo, only dexamethasone 8mg via submucosal injection effectively reduced pain in the first and second days after 3MS (-30.95[-43.41; -18.49]) and (-15.25[-23.27; -7.22]), respectively. Overall, corticosteroids reduced inflammatory complications after 3MS and did not show any serious adverse effects. Among the corticosteroids reviewed, dexamethasone 8mg was the best preoperative option to control inflammatory complications after 3MS. Further RCTs are needed to confirm the optimal route of administration.

What grafting materials produce greater alveolar ridge preservation after tooth extraction? A systematic review and network meta-analysis.

A systematic review and network meta-analysis was conducted to compare different bone-substitute materials used for alveolar ridge preservation after tooth extraction. The electronic search was carried out on Embase, PubMed, Cochrane Library, Web of Science, Scopus, LILACS, and grey literature up to March 22, 2020 (registration number INPLASY202030005). Only randomized controlled trials were included to answer the following PICOS question: 'What grafting materials produce greater alveolar ridge preservation after tooth extraction?' The primary outcomes were the alveolar width resorption 1 mm below the alveolar crest and buccal height resorption in millimeters. Of the 4379 studies initially identified, 31 studies involving 1088 patients were included in the quantitative analyses. Out of 25 revised biomaterials, eight showed a statistically significant difference compared with unassisted healing in both alveolar width and height measurements (mean width differences: ApatosⓇ, 2.27 [1.266-3.28]; Bio-OssⓇ, 0.88 [0.33-1.42]; Bio-Oss CollⓇ, 0.53 [0.04-1.01]; Bond-apatiteⓇ, 2.20 [1.30-3.11]; freeze-dried bone allograft, 1.35 [0.44-2.26]; Gen-OsⓇ, 1.90 [0.60-3.20]; platelet-rich fibrin, 1.66 [0.66-2.67]; and MP3Ⓡ, 2.67 [1.59-3.75]). Overall, xenograft materials should be considered as among the best of the available grafting materials for alveolar preservation after tooth extraction.

Intrasocket interventions to prevent alveolar osteitis after mandibular third molar surgery: A systematic review and network meta-analysis.

A systematic review and network meta-analysis was carried out to assess the efficacy of different intrasocket interventions immediately after mandibular third molar surgery to prevent alveolar osteitis (AO). An electronic search was undertaken using EMBASE, Cochrane Library, MEDLINE/PubMed, Web of Science, Scopus, LILACS, and grey literature. We reviewed studies published up to September 2019 and included 37 randomized controlled trials (6175 mandibular third molar surgeries in 4716 patients). The pairwise meta-analysis showed that the incidence of AO decreased significantly when an intrasocket intervention was performed (risk ratio 0.39 [0.30, 0.52]; p < 0.0001). Platelet-rich fibrin (odds ratio 0.28; 95% CI [0.10, 0.71]), chlorhexidine gel 0.2% (0.52 [0.32, 0.95]), eugenol paste (0.06 [0.00, 0.77]), recombinant bovine growth factor (0.07 [0.00, 0.97]), colloidal silver gelatin sponge (0.05 [0.00, 0.74]), and acellular dermal matrix (0.04 [0.00, 0.74]) were significantly more effective than the placebo. Platelet-rich fibrin and chlorhexidine 0.2% gel had a large number of included studies and patients per comparison. Overall, there was moderate evidence to support the use of platelet-rich fibrin or chlorhexidine 0.2% gel in the socket for the prevention of AO after mandibular third molar surgery.

Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial.

The use of platelet concentrate in alveolar ridge preservation has been broadly studied. However, no randomized clinical trials with histomorphometric analysis and low risk of bias are available in the literature. We conducted a prospective, single-blind, parallel, randomized, controlled clinical trial to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in socket preservation after tooth extraction. Additionally, the effect of L-PRF on bone formation was analyzed histologically using bone biopsy specimens obtained during implant placement. A total of 48 subjects who underwent a non-molar tooth extraction were randomly assigned to the L-PRF group (n = 24) or the control group (n = 24). Cone-beam computed tomographies were performed immediately after tooth extraction and at 3 months after tooth extraction, prior to implant surgery. A significant difference in bone resorption was registered 1 mm below the crest: 0.93 ± 0.9 mm for the L-PRF group and 2.27 ± 1.2 mm for the control group (p = 0.0001). Histomorphometric analysis showed a higher percentage of new bone formation in the L-PRF group compared with the control group. The values were 55.96 ± 11.97% and 39.69 ± 11.13%, respectively (p = 0.00001). These findings indicate that the administration of L-PRF should always be considered when socket preservation is planned (Clinicaltrials.gov NCT03408418).

Which is the best choice after tooth extraction, immediate implant placement or delayed placement with alveolar ridge preservation? A systematic review and meta-analysis.

A comprehensive literature search on implant placement protocols after tooth extraction (immediate, early, delayed, or later) was performed up to 2018. The screening process selected only randomized clinical trials (RCTs) from PubMed, Embase, Cochrane Library, Web of Science, Scopus, LILACS, and grey literature. A series of pairwise meta-analyses was carried out to evaluate implant performance in each protocol. The primary outcomes were implant survival and esthetic outcome, measured by pink esthetic score (PES), and the secondary outcomes were peri-implant bone resorption and implant complications. The outcomes were at least 1 year after implant surgery. A total of 5056 studies were found, of which 16 were included for qualitative analysis and 9 for quantitative analysis. The meta-analysis showed increased risk of implant failure by 3% in the immediate implant protocol. PES analysis showed no statistical significant difference between immediate or delayed protocols (p = 0.16). However, the subgroup analysis showed that the anterior region presented better results with immediate implants, while the molar region presented better results with delayed implants. The quantitative analysis showed no statistical difference in peri-implant bone resorption between the immediate and delayed implant protocols (p = 0.42). Due to the lack of studies with a low risk of bias, further RCTs are needed for definitive conclusions.

Sleep-disordered breathing following mandibular setback: a systematic review of the literature.

INTRODUCTION: A mandibular setback reduces space in the pharyngeal airway, and it has been suggested that it might induce sleep-disordered breathing. OBJECTIVES: An evidence-based literature review was conducted to identify the effect of mandibular setback on the respiratory function during sleep. METHODS: The authors performed a systematic review of pertinent literature published up to 2014. A structured search of literature was performed, with predefined criteria. A survey of the PubMed, ScienceDirect, and Cochrane database was performed. A manual search of oral and maxillofacial surgery-related journals was accomplished. Potentially relevant studies then had their full-text publication reviewed. RESULTS: A total of 1,780 publications were evaluated, through which nine papers (seven case series and two case-control studies) were selected for the final review. No evidence of sleep disorder after six months was related in 223 patients. In one study, two patients developed obstructive sleep apnea syndrome after surgery, and in another two studies, seven patients presented an increase of obstructive apneas/hypopneas events and oxygen desaturation index. Most of the patients analyzed were young and thin. CONCLUSION: There was no evidence of postoperative sleep apnea syndrome after a mandibular setback surgery. However, one should always consider a potential reduction of the upper airway space during the treatment plan. Obese patients and those submitted to large amounts of mandibular setbacks present a higher chance to develop obstructive sleep apnea syndrome.

Estudo das alterações volumétricas faríngeas após cirurgia ortognática em pacientes classe III e sua influência no desenvolvimento da apneia obstrutiva do sono / Study of pharyngeal volumetric changes after orthognathic surgery in class III patients and its influence in obstructive sleep apnea

A cirurgia ortognática para correção da maloclusão dentária classe III gera modificações na via aérea faríngea (VAF) que podem predispor à Síndrome da Apneia Obstrutiva do Sono (SAOS). O objetivo deste estudo foi avaliar, através de tomografia computadorizada por feixe cônico, as modificações imediatas na VAF de pacientes classe III submetidos à cirurgia ortognática, verificando sua influência no desenvolvimento da SAOS, e correlacionando o movimento do osso hióideo com as modificações na VAF. Foi utilizado para diagnóstico da SAOS o questionário de Berlim, a escala de Sonolência de Epworth e alguns sintomas sugestivos através de 2 entrevistas, uma antes e outra 6 meses após a cirurgia. Realizou-se um estudo prospectivo com 33 pacientes divididos em 3 grupos: recuo de mandíbula isolado (9 pacientes), cirurgia maxilomandibular (18 pacientes) e avanço de maxila isolado (6 pacientes). As medidas obtidas da VAF no pré e no pós-operatório foram comparadas utilizando o teste t pareado, enquanto a correlação entre osso hióideo e as modificações da VAF foram analisadas através do coeficiente de correlação de Spearman. O grupo de pacientes submetidos ao recuo de mandíbula isolado apresentou alterações morfológicas mais pronunciadas, com redução no volume total da VAF, no volume da hipofaringe e na área de maior constrição (p<0,05). Observou-se uma correlação positiva forte entre o deslocamento horizontal do osso hióideo e a diminuição da área de maior constrição (r=0,712). O exame clínico não diagnosticou a SAOS em nenhum dos pacientes após 6 meses da cirurgia. O estudo não encontrou evidências de que a cirurgia ortognática para correção da maloclusão classe III predispõe à SAOS.

The orthognathic surgery for correction class III malocclusion, generates changes in the pharyngeal airway space (PAS) which may predispose to obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate, through cone beancomputed tomography, theimmediate changes in the PAS in Class III patients submitted to orthognathic surgery, evaluating the influence of surgery in the development of OSAS, and correlating the position of the hyoid bone with measurements of PAS.For diagnosis of OSAS, Berlin questionnaire, Epworth Sleepiness Scale, and some characteristics symptoms, were searched through 2 interviews, one before surgery, and another 6 months after.This prospective study included 33 patients divided into 3 groups: mandibular setback surgery (9 patients), bimaxillary surgery (18 patients) and maxillary advancement surgery (6 patients). The measures obtained from the PAS pre- and postoperatively were compared using paired t test, and the correlation between the hyoid and PAS measurements, using the Spearman correlation coefficient. Patients undergoing mandibular setback surgery showed more pronounced morphological changes,with a decrease in the total volume of the PAS, in the volume of the hypopharynx, and in minimum cross-sectional area (p <0.05). There was a strong correlation between the horizontal displacement of the hyoid bone and reduction ofminimum cross-sectional area (r = 0.712). Clinical analysis did not diagnose OSAS in any patients 6 months after surgery. There was no evidence that orthognathic surgery, for correction of malocclusion class III, predispose to OSAS.

Intubación submentoniana en cirugía buco-maxilofacial / Submental intubation in oral and maxillofacial surgery

Intubación submentoniana es un procedimiento seguro y efectivo para el manejo de las vías respiratorias en pacientes con fracturas múltiples en la cara. Es utilizada en los casos en que la intubación oral y nasal son contraindicadas, como la necesidad de bloqueo maxilomandibular en transoperatorio o en fracturas cuya extensión que presentan el riesgo de lesiones en la base del cráneo, respectivamente. Presenta todavía un menor índice de complicaciones y riesgos en comparación con la traqueotomía siendo una alternativa a la misma. El objetivo de la obra es relatar un caso de un paciente con fracturas múltiples en la cara en la cual fue utilizada la intubación submentoniana para el mantenimiento de las vías respiratorias.

Intubação submentoniana é um procedimento seguro e eficaz para a manutenção das vias aéreas em pacientes com múltiplas fraturas na face. É utilizada em casos nos quais a intubação oral e a nasal são contraindicados, tais como a necessidade de bloqueio maxilomandibular durante a cirurgia ou em fraturas cuja extensão apresentam risco de lesões para a base do crânio, respectivamente. Apresenta uma menor taxa de complicações e riscos, quando comparado à traqueostomia, portanto sendo uma alternativa. O objetivo deste artigo é relatar um caso de um paciente com múltiplas fraturas na face em que foi utilizada a intubação submentoniana para manutenção das vias aéreas.